Elevated soluble TIM-3 (sTIM-3) may serve as a potential biomarker for the prediction of the disease activity of sepsis [4], systemic lupus erythematosus (SLE) [5], adultonset Still’s disease [6], autoimmune hepatitis [7] and COVID-19 [8, 9]. This evidence concerns the gene HAVCR2 and systemic lupus erythematosus.