The other five TCR, which were HLA-B*07:02, HLA-B*15:01, HLA-B*40:01 and HLA-C*07:02 restricted and recognize the E615–23, E743–52, E778–86 and E653–61 epitopes respectively, displayed clear recognition of endogenously processed E6 or E7 antigen after transduction into primary human T cells (Fig. 3) Interestingly, five of the six TCRs with good recognition of endogenous E6 or E7 antigen in K562 cells also targeted naturally processed antigen in tumor cells. Here, HLA-C is linked to neoplasm.