Given that MIP-1α is found to be highly expressed in PBMC and BAL of COVID-19 patients56, particularly with severe disease57, and IL-1Ra has important regulatory effects on IL-1 mediated inflammatory responses, our results showing an inverse correlation of BAL Vδ1 T cell frequencies with levels of MIP-1α and positive correlation with IL-1Ra, suggest that Vδ1 T cells may be protective against developing severe disease by modulating early inflammatory signaling in response to SARS-CoV-2 infection in the lungs. This evidence concerns the gene IL1B and COVID-19.