CD8A and neoplasm: In the tumor center, the mean numbers of the two cell types (CD8-TC and TAN-TC) were highest and did not differ statistically from each other (CD8-TC vs TAN-TC; p = 0.69), Fig. 2A. Similarly, the mean numbers of the other two cell types (CD4-TC and CD3-TC) were the lowest, did not differ statistically from one another (CD4-TC vs CD3-TC; p = 0.87), and simultaneously were lower than the first two (CD4-TC vs CD8-TC; p < 0.0001.