CDO1 and non-small cell lung carcinoma: In line with the previous findings in NSCLC cells, CDO1 restoration in GC cells elicited oxidative stress as evidenced by elevated ROS, reduced GSH/GSSG and NADPH, as well as damages to respiratory function of mitochondria et al. However, we did not observe that CDO1 triggered cellular death, such ferroptosis, in GC cells (Supplementary Fig. 5).