IRF4 and neoplasm: Higher levels of activity of regulons related to the immune system (such as STAT2 and FOXP3) and its developmental processes (IRF4, IRF8) were found in cluster LCH_1, while cluster LCH_0 had higher levels of regulon activity in processes related to both oncogenesis and tumor suppression, that is, ELF1, HDAC2, MYC and p53 regulons (Fig. S4F, G).