Higher levels of activity of regulons related to the immune system (such as STAT2 and FOXP3) and its developmental processes (IRF4, IRF8) were found in cluster LCH_1, while cluster LCH_0 had higher levels of regulon activity in processes related to both oncogenesis and tumor suppression, that is, ELF1, HDAC2, MYC and p53 regulons (Fig. S4F, G). This evidence concerns the gene IRF8 and neoplasm.