The high incidence of hypertension among individuals with diabetes is attributed to different structural alterations secondary to endothelial dysfunction, insulin resistance in the nitric-oxide pathway, sodium fluid retention, the stimulatory effect of hyperinsulinemia on the sympathetic nervous activity, and the excitatory effect of hyperglycemia on renin-angiotensin-aldosterone system [1, 5–7]. The gene discussed is REN; the disease is diabetes mellitus.