According to this, the ayahuasca compound dimethyltryptamine (DMT) agonizes the sigma 1 receptor (Sig-1R) and thereby regulates endoplasmic reticulum (ER) stress and Unfolded Protein Response (UPR), which are thought to play a crucial role in neuropsychiatric diseases such as AD. This evidence concerns the gene SIGMAR1 and Alzheimer disease.