NFE2L2 and cancer: NRF2 activation has been linked to cancer progression and metastasis and has been suggested to confer resistance to chemotherapy (Homma et al., 2009; Jiang et al., 2010; Konstantinopoulos et al., 2011; Romero et al., 2017; Shibata et al., 2008; Singh et al., 2006).