2016). Studies demonstrated that EZH2 expression was upregulated in renal fibrosis induced by the murine model of UUO or TGF-β stimulated, which contributed tubular epithelial EMT and fibrosis by downregulating expression of PTEN, thus activating multiple profibrotic signaling pathways (Zhou et al. 2018). The gene discussed is EZH2; the disease is renal fibrosis.