In the current study, we identified 28 TFs with the 3 TFs MXD3, ZNF580, and KDM1A significantly correlated to the PVT1/DUSP13 axis with moderate correlation (all with absolute Pearson correlation coefficients reaching 0.3) experimentally validated in the HCC cell line HepG2 using the ChIP assay. Here, DUSP13A is linked to hepatocellular carcinoma.