Largely consistent with previous studies showing the immune infiltration state and immune‐related genes played a pivotal role in HCC with MVI,53, 54 our data showed that the DUSP13 level was significantly associated with the immune score and immune infiltration by the naïve B cell, CD8 T cell, resting memory CD4 T cell, activated memory CD4 T cell, and macrophage M1 in the MVI but not non‐MVI group, suggesting great tuning potential by immunotherapy. This evidence concerns the gene CD4 and hepatocellular carcinoma.