In the current study, we identified 28 TFs with the 3 TFs MXD3, ZNF580, and KDM1A significantly correlated to the PVT1/DUSP13 axis with moderate correlation (all with absolute Pearson correlation coefficients reaching 0.3) experimentally validated in the HCC cell line HepG2 using the ChIP assay. The gene discussed is MXD3; the disease is hepatocellular carcinoma.