GFM1 and Nephropathy: We find that NOTCH3 ECD depositions around capillaries as well as NOTCH3 ECD levels in the blood are reduced in CADASIL mice treated with the NOTCH3 EGF1–5‐directed vaccine for 4 months and that the vaccine does not appear to interfere with the role of Notch signaling for vascular integrity or induce inflammation, neurodegeneration or kidney damage.