used scRNA-seq to explore the immune status of BALF in patients with asthma exacerbations and found increased levels of CD8+ T cells, several monocyte clusters, and a monocyte-derived macrophage subset (39).They also found that an additional group of core exacerbation-associated modules was activated, including eukaryotic initiation factor 2 signaling, ephrin receptor signaling, and C-X-C chemokine receptor type 4 signaling in the subpopulations of CD8+ T cells (C1-a) and monocyte clusters (C7 clusters), which were associated with infection. The gene discussed is CD8A; the disease is infection.