REN and atherosclerosis: The result suggested that DEGs were related to multiple pathways such as ‘cell adhesion molecules’, ‘leukocyte transendothelial migration’, ‘renin-angiotensin system’, ‘vascular smooth muscle contraction’, ‘protein digestion and absorption’, ‘axon guidance’, ‘PPAR signaling pathway’, ‘tight junction’, ‘tyrosine metabolism’, ‘steroid hormone biosynthesis’, ‘calcium signaling pathway’, ‘fluid shear stress and atherosclerosis’, ‘focal adhesion’, ‘complement and coagulation cascades’, ‘renin secretion histidine metabolism’, ‘p53 signaling pathway’, and ‘apoptosis’ (Supplementary Table 3).