TGFB1 and endothelial dysfunction: Its activation causes a series of biological effects such as vasoconstriction, endothelial dysfunction, platelet activation, activation of platelet-derived growth factor (PDGF) and transforming growth factor beta (TGFβ), causing cell proliferation, and interstitial fibrosis, etc. AGTR1 is highly expressed in epithelial ovarian cancer and is thought to be closely related to the migration, invasion and tumor progression of endometrial cancer cells (41, 42).