Aged mice lacking Ccr2, its ligand Ccl2 or Cx3CR1 have been shown to develop retinal lesions that are reminiscent of human AMD (240, 259–263) and, indeed, mutations in CX3CR1 gene have been found also in patients affected by AMD (259, 264–267), but not mutations in CCR2 (268). Here, CX3CR1 is linked to age-related macular degeneration.