CIC and thalassemia: In cluster1, the following three genes ranked by frequency were alpha-thalassemia/mental retardation syndrome x-linked chromatin remodeler (ATRX) (22%), epidermal growth factor receptor (EGFR) (16%), and titin (TTN) (16%), while those in cluster2 were ATRX (29%), CIC (19%), and TTN (14%).