Of the ELISA-validated protein combinations for assessing disease exacerbation, including PHACTR2, GOT2, L-selectin, CMC4, MAP2K1, CMPK2, ECPAS, SRA1, and STAT2, the biomarker combination exhibited an ROC AUC value of 0.990 in terms of distinguishing active SLE patients from inactive SLE patients. This evidence concerns the gene CMC4 and systemic lupus erythematosus.