Compared to HC samples, IFIT3, MX1, STAT1, STAT2, and OAS3 were all significantly upregulated in memory B cell clusters in SLE samples, and IFIT3, MX1, and OAS3 were significantly upregulated in naïve CD4 T, TEM CD4 T, TEM CD8 T, MAIT T, and Mk clusters. This evidence concerns the gene OAS3 and systemic lupus erythematosus.