Of the ELISA-validated protein combinations for assessing disease exacerbation, including PHACTR2, GOT2, L-selectin, CMC4, MAP2K1, CMPK2, ECPAS, SRA1, and STAT2, the biomarker combination exhibited an ROC AUC value of 0.990 in terms of distinguishing active SLE patients from inactive SLE patients. The gene discussed is STAT2; the disease is systemic lupus erythematosus.