So far, STAT5B mutations are rare and tend only to be found in human myeloid leukemia such as CD4+ T-cell prominent granular lymphocytic (T-LGL) leukemia, chronic natural killer lymphoproliferative disorders (CLPD-NK), Acute promyelocytic leukemia (APL) (40, 41). Here, STAT5B is linked to myeloid leukemia.