transduced human Epstein Barr virus (EBV)-specific cytotoxic T cells with CD33 CAR, and the CAR-T cells displayed EBV and HLA-unrestricted bispecificity in vitro and anti-AML tumor activity in CD33+ human AML-bearing mice without irreversibly disrupting the formation of CD34(+) hematopoietic progenitor clones (124). The gene discussed is CD33; the disease is neoplasm.