To be more specific, TNFSF4, CD86, PDCD1LG2, TNFRSF4, HAVCR2, CD28, TNFSF18, TNFRSF9, PTPRC, PDCD1, IL12B, CD80, JAK1were significantly highly expressed in gastric tumor tissues and cluster II that associated with worse OS. The gene discussed is PDCD1LG2; the disease is gastric neoplasm.