METTL3 and cancer: In previous investigations, the immune-related genes or m6A-related regulators signatures for prognostic prediction have been studied in a variety of cancers, such as lung Adenocarcinoma (44, 45), hepatocellular carcinoma (46, 47), etc. Similarly, based on the differentially expressed immune-related genes or m6A-related regulators, several prognostic signatures have also been established to predict the outcome of GC patients.