Mice with Maspin-expressing prostate cancer xenograft had an increased expression of Maspin-specific immunoglobulin G (IgG), and Maspin-expressing tumors could induce neutrophil infiltration with increased systemic and intratumoral neutrophil maturation, implying that Maspin elicits neutrophils and B cells for the host immunity to benefit tumor clearance. Here, SERPINB5 is linked to Familial prostate cancer.