CASP3 and non-small cell lung carcinoma: Additionally, they found that several kirsten rat sarcoma virus (KRAS), the epidermal growth factor receptor (EGFR), or anaplastic lymphoma kinase (ALK) small molecule targeted inhibitors uniformly activate the mitochondrial intrinsic apoptotic pathway to facilitate caspase-3 cleavage of GSDME to induce NSCLC cell pyroptosis, in addition, to concurrently inducing cellular apoptosis.