found that both chemotherapeutics paclitaxel and cisplatin (DDP) could induce pyroptosis in A549 cells, the pyroptosis induction by DDP was more severe than that caused by paclitaxel, suggesting that DDP may be more preferable than paclitaxel for the treatment of NSCLC with high GSDME expression (58). This evidence concerns the gene GSDME and non-small cell lung carcinoma.