discovered that conventional chemotherapeutic drugs are able to cause cell death via pyroptosis when tumor-expressing gasdermin E (GSDME) is cleaved by activated caspase-3 to form GSDME-N-terminal (GSDME-NT) and GSDME-C-terminal (GSDME-CT) in various cancers. The gene discussed is CASP3; the disease is neoplasm.