Meanwhile, the expression level of GSDME in lung cancer tissue is significantly higher than that in adjacent tissue, patients with lung cancer having a high GSDME expression have less lymph node metastasis and longer postoperative survival, although the decrease in GSDME level was not significantly correlated with tumor size, clinical stage, age, or tumor recurrence rate (55, 110). This evidence concerns the gene GSDME and metastatic malignant neoplasm in the lymph nodes.