SDC1 and Carcinoma, Lewis Lung: found that SCGB3A2 chaperones LPS to the cytosol through the heparan sulfate (HS) of the cell surface receptor syndecan-1 (SDC1) and activates the caspase-11/NLRP3/GSDMD pathway to lead to pyroptosis in murine Lewis lung carcinoma (LLC) cells (96).