Additionally, knockdown or reduction of NLRP3 expression significantly promoted NSCLC cell viability and decreased the IL-1β and IL-18 expression, suggesting that NLRP3-caspase-1-IL-1β and IL-18 inflammation pathways play an important antitumor role in NSCLC (65, 66). The gene discussed is CASP1; the disease is non-small cell lung carcinoma.