Tumor suppression caused by overexpression of adenosine deaminase RNA-specific B1 (ADARB1) is the result of DNA demethylation signal transduction, and inactivation of DNA methylation using a DNA methyltransferase inhibitor significantly enhances ADARB1-mediated metastatic inhibition of LUAD cells (109). This evidence concerns the gene ADARB1 and neoplasm.