PPIF and breast carcinoma: In other types of tumors or diseases, PGAM5 is used as a mediator of signaling pathways, such as the RIP1/RIP3/PGAM5 pathway in breast cancer (38), the PGAM5-CypD pathway in prolactinoma (39), and the Ripk3/Pgam5 signaling pathway in septic cardiomyopathy, to induce necroptosis (40).