SIRT7 expression is increased in PTC tissues as well as in the PTC cell lines FTC133, 8505C, TPC1, BCPAP, IHH4 and K1, in addition, SIRT7 knockdown remarkably inhibited proliferation, colony formation, migration and invasion, and also induced cycle arrest and apoptosis in PTC cancer cells, SIRT7 promotes thyroid tumorigenesis through phosphorylation of the promoter of deleted in breast cancer 1 (DBC1)/SIRT1 axis and activation of AKT and p70S6K1 in BALB/c lymphatic-free mice (47). The gene discussed is AKT1; the disease is thyroid gland disorder.