HDAC2 and neoplasm: In fact, HDAC1 and HDAC2 expression levels are mildly increased in PTC tissues relative to normal tissues (37), Nuclear receptor binding protein 2 (NRBP2) reduces TC tumorigenesis and M2 macrophage infiltration in vivo, GATA binding protein 1 recruits HDAC2 to the NRBP2 promoter region, inhibits NRBP2 expression by reducing H3K9ac levels, blocks NRBP2 inhibition in PTC histiocytes and BCPAP and TPC-1 cell lines, and thereby promotes the formation of tumor microenvironment(TME) and activates angiogenesis (38).