IL1R1 and Anxiety: Pharmacological and genetic intervention strategies using adrenergic receptor antagonists, microglial activation blockers, cell specific IL-1R transgenic mice highlight a key role of sympathetic activation, microglia-mediated trafficking of reactive IL-1β- releasing monocytes to the brain, and the recruitment of endothelial and neuronal IL-1R1 in promoting RDS induced expression of anxiety-associated behaviors and reduced social interaction (184–187).