Previously, AQP4 was well-descripted as brain-specific regulator and in recent years, there has emerged an intriguing and surprising link between AQP4 and brain tumors (Ding et al., 2010; Yang et al., 2012; Zhao et al., 2012; Papadopoulos and Saadoun, 2015). This evidence concerns the gene AQP4 and brain neoplasm.