NTSR1 and schizophrenia: Loss of NTSR1 function established a role in dopaminergic reward, managing features associated with schizophrenia (Mechanic et al., 2009; Liang et al., 2010), and established a lack of involvement in analgesia which is mediated through NTSR2 (Pettibone et al., 2002; Remaury et al., 2002; Maeno et al., 2004; Mechanic et al., 2009).