IFNG and major depressive disorder: The IFN-γ-dependent inflammatory response was already proved on primary murine microglia, microglia in hippocampal slice cultures resulting in cognitive impairment and depression-like behavior, and on human iPSC-microglia to boost LPS-activation and recapitulate the LPS-dependent response described in mouse microglia (Lively and Schlichter, 2018; Ta et al., 2019; Zhang J. et al., 2020; Jiang et al., 2021; Kenkhuis et al., 2022; Monzón-Sandoval et al., 2022).