Nonetheless, another possible mechanism involved in the protection of patients with asthma is the inflammatory micro- and macro-environment created by the pathological process that would reduce the expression of ACE-2 receptors that would suffer downregulation due to the expression of IL-13 secreted by local eosinophils, cells related to the pathophysiological process of asthma as already exposed and with the recovery of patients who were contaminated by SARS-CoV-2 (4, 17). This evidence concerns the gene IL13 and asthma.