AKT1 and prion disease: The top 10 Pathways included: Antigen processing and presentation, PI3K-Akt signaling pathway, Bladder cancer, Complement, and coagulation cascades, Staphylococcus aureus infection, Melanoma, p53 signaling pathway, AGE−RAGE signaling pathway in diabetic complications, Prion diseases, Focal adhesion (Figure 6).