CDKN2A and atherosclerosis: Knösel et al, (2014) reported that CDKN2A upregulation is linked to oncogene-induced aging, whereas CDKN2A loss potentially triggers malignant progression. Additionally, Bayoglu et al, (2014) reported that upregulated CDKN2A gene expression in arterial plaques increases the risk of atherosclerosis and promotes carotid stenosis development.