Blocking of the sodium-glucose cotransporter-2 can, in an insulin-independent way, enhance glucose excretion from urine and decrease blood glucose levels, The administration of hypoglycemic drugs such as ertugliflozin, along with blood sugar level regulation, has significantly reduced the incidence of therapy-induced hypertension, obesity, and dose-related hypoglycemia [4]. This evidence concerns the gene INS and Hypoglycemia.