While it seems likely that the reduced renal levels of YAP and YAP target genes, including Myc, that we show here in female RC/RC:Casp1 KO mice contribute to their suppressed cystic disease, the specific contribution of this pathway to direct effects on tubule cell proliferation or to the inflammatory environment influencing cyst growth has not yet been studied. The gene discussed is CASP1; the disease is cyst.