MYC and autosomal dominant polycystic kidney disease: Since the initial discovery of elevated renal MYC levels in a non-orthologous model of PKD (Cowley et al., 1987), this protein and MYC-stimulated pathways have been found to be elevated in all models of PKD that have been examined, as well as in human ADPKD (Trudel, 2015; Kurbegovic and Trudel, 2020).