NLRP3 and autosomal dominant polycystic kidney disease: Finally, we show that treatment of RC/RC mice with the anti-inflammatory drug HCQ, which can inhibit the NLRP3/Caspase-1 inflammasome among its effects, both protects kidney function in females and restrains cystic growth in both females and males, suggesting its potential use in the treatment of ADPKD patients.