CYP2J2 and cancer: Cytochrome P450 2J2 (CYP2J2), a member of the cytochrome P450 superfamily of enzymes, can metabolize linoleic acid to 9,10-epoxyoctadecaenoic acids(9,10-EpOME) and 12,13-epoxyoctadecaenoic acids (12,13-EpOME). EpOMEs have been reported to have cancer-promoting activity in a mouse model of CRC (Wang et al., 2019).