PIK3CA and colorectal carcinoma: Interestingly, these are also the molecular characteristics of right-sided CRC (Dekker et al., 2019), and the proportions of CRC with specific molecular features such as MSI-H, CIMP-H, and BRAF and PIK3CA mutations gradually increase along the bowel subsites from rectum to ascending colon (Yamauchi et al., 2012).