The co-treatment of CRC cells with Fn and DSS increases the phosphorylated levels of EGFR, inducing the activation of downstream effector kinases, including protein kinase B (AKT) and extracellular signal-regulated kinase (ERK), finally leading to the upregulation of EMT transcription factor Snail and mesenchymal markers fibronectin and N-cadherin, the downregulation of epithelial markers E-cadherin and ZO-1. Here, CDH1 is linked to colorectal carcinoma.