SNCA and muscle tissue disorder: In our analysis of the pathological role of α-synuclein, it was highest implicated in neurological diseases (P 2.34 e−57), followed by organismal injury and abnormalities (P 6.21 e−56), skeletal and muscular disorders (P 4.55 e−53), psychological disorders (P 1.96 e−47), and hereditary disorders (P 6.27 e−43; Figure 2D; Supplementary Figure S7).