The expression and toxicity analyzes of α-synuclein identified TREM1, phagosome maturation, and sirtuin signaling pathways associated with the physiological functions of α-synuclein, whereas PD, sumoylation, and SNARE signaling pathways were identified as specific to the toxicity of α-synuclein. The gene discussed is TREM1; the disease is Parkinson disease.