The toxicity analysis of APP predicted docosahexaenoic acid (DHA) signaling (P 1.82 e−03), amyloid processing (P 2.4 e−03), neuroprotective role of thimet oligopeptidase (THOP1) in AD (P 5.37 e−03), reelin signaling in neurons (P 6.62 e−03), mitochondrial dysfunction (P 7.91 e−03), inhibitor of differentiation-1 (ID1 signaling (P 9.59 e−03), neurovascular coupling signaling (P 1.03 e−02), sirtuin signaling (P 1.37 e−02), and neuroinflammation signaling (P 1.47 e−02) pathways as the mediators of amyloid beta toxicity (Figure 4B). The gene discussed is RELN; the disease is Alzheimer disease.