Neuroinflammation (P 4.78 e-18) was the most prominent of the predicted signaling pathways for α-synuclein followed by Huntington’s disease (P 4.34 e−11), triggering receptor expressed on myeloid cells 1 (TREM1; P 1.28 e−10), phagosome maturation (P 2.96 e−11), and sirtuin signaling pathways (P 5.50 e−10; Figure 2A). The gene discussed is SNCA; the disease is juvenile Huntington disease.