Although there is no study on increasing the expression of CADM1 through regulating associated miRNAs in PTC up to now, there are some studies on other cancers: inhibiting microRNA-1246 can increase the expression of CADM1 in hepatocellular carcinoma (50); upregulating miR-486 can downregulate CADM1 expression in Ovarian Cancer (51); miR-155-3p could downregulate expression of CADM1 in breast cancer (33). The gene discussed is CADM1; the disease is cancer.