reported the downregulation of CADM1 was able to activate the P44/42 MAPK signaling pathway associated with cell proliferation, migration and invasion (41), and CADM1 acts as an inhibitor of the RAS-RAF-MEK1/2-ERK1/2 pathway to inhibit the EMT in melanoma (42),which are consistent with our thought. This evidence concerns the gene MAP2K1 and melanoma.