CADM1 and neoplasm: No matter molecular mechanisms regulated or cell death involved by CADM1-CADM1, they all play an important role in tumor resistance, thus, we further studied the influence of CADM1-CADM1 on targeted drugs using pRRophetic package in R. Surprisingly, the high expression of CADM1-CADM1 strongly increased the sensitivity of many targeted drugs such as Erlotinib, MG-132, AZ628 (Figure 9), which meant therapeutic effects of targeted drugs could be improved by upregulating the expression of CADM1-CADM1.