In M-ABs, SOCE via the Orai1-Stim1 complex has been suggested to be the main calcium influx pathway (Nurbaeva et al., 2017), and patients with loss-of-function or null mutations in the STIM1 and ORAI1 genes present with a hypocalcified form of amelogenesis imperfecta (Mccarl et al., 2009; Picard et al., 2009; Fuchs et al., 2012). This evidence concerns the gene ORAI1 and amelogenesis imperfecta.