TLR8 and nonpapillary renal cell carcinoma: To be more specific, the expression of NET-related genes SELPLG, LILRB2, ITGB2, CSF3R, ITGAM, TLR2, CREB5, TLR7, DYSF, TLR8, MMP9, CYBB, PTAFR, SIGLEC14, FPR1, and SLC22A4 was upregulated, while the expression of DNASE1, MTOR, CYP4F3, F3, SELP, KCNJ15, and G0S2 was downregulated in ccRCC (Figure 1C, p < 0.001).