IGF1 and stroke disorder: Studies suggest that microglial cells may limit post-stroke inflammation by phagocytizing dead cells and neutrophils, generating neurotrophic factor IGF-1 and inhibiting astrocyte activation, and the depletion of microglial cells worsens stroke outcomes (Lalancette-Hébert et al., 2007; Jin et al., 2017; Otxoa-de-Amezaga et al., 2019).