Two studies in AD models indicate that IL-10 worsens amyloid-related symptoms in mice and also involve microglial IL-10 in increasing astrocytic production of ApoE, which subsequently loops back to decrease microglial attraction for Aβ (Chakrabarty et al., 2015; Guillot-Sestier et al., 2015). This evidence concerns the gene IL10 and Alzheimer disease.