LncRNA MEG3 expression was significantly increased in the temporal cortex of rats with subarachnoid hemorrhage and in the cerebrospinal fluid of patients with subarachnoid hemorrhage, while the expression of the PI3K/Akt signaling pathway was decreased, which promoted neuronal apoptosis (Liang et al., 2018). This evidence concerns the gene AKT1 and subarachnoid hemorrhage.