The inhibition of Meg3 prevents cardiac fibrosis and diastolic dysfunction (Piccoli et al., 2017), and the downregulation of MEG3 protects myocardial cells against I/R-induced apoptosis through the miR-7-5p/PARP1 pathway (Zou et al., 2019) Chao He et al. found in their study that MEG3, as a ceRNA, inhibits miR-9, affects the phenotype of MEG3-mediated vascular endothelial cells (He et al., 2017). The gene discussed is MEG3; the disease is fibrosis.