MEG3 and neoplasm: Second, MEG3 expression is associated with WHO grade of tumor, old age at diagnosis, Karnofsky performance score (KPS), wild-type isocitrate dehydrogenase (IDH), tumor recurrence and overall survival, which is of prognostic value (Gong and Huang, 2017; Zhao et al., 2018; Buccarelli et al., 2020).