MEG3 and cancer: For example, MEG3 functions as a competing endogenous RNA to regulate cancer progression, reduces mitochondrial-derived apoptosis (Wang et al., 2021a), participates in the regulation of tumor drug resistance (Yu et al., 2020), participates in glaucoma onset (Sun et al., 2018), etc., This noncoding RNA is not only involved in the pathogenesis of many diseases but also found in an increasing number of mechanisms.