MEG3 and pulmonary fibrosis: Downregulation of MEG3 or FOXO1 can lead to decreased autophagy of INS-1 cells induced by high glucose.1During pulmonary fibrosis, downregulation of MEG3 activates the Hedgehog (Hh) signaling pathway and inhibits autophagy activity of A549 cells (Gao et al., 2022).