MAPK1 and gastric cancer: Although Paeoniae Radix Alba reversed the drug resistance of GC cells, the mechanism was unknown until paeonol (the active compound in Paeoniae Radix Alba) was reported using genomics—data showed that paeonol inhibited the malignancy of apatinib-resistant GC cells through the LINC00665/miR-665/MAPK1 axis (Li et al., 2022b).