Alterations in P62 may be therapeutic specific, such that chemotherapy-induced autophagy increases LC3-II without altering P62, whereas radiation-induced autophagy increases LC3-II and reduces P62 in murine breast cancer cells overexpressing ERBB2/her2 (Toepfer et al., 2011; Zheng et al., 2011; Aqbi et al., 2018). Here, ERBB2 is linked to breast cancer.