Abnormal chemerin/CMKLR1 axis closely correlates with several diseases including inflammatory diseases (rheumatoid arthritis, lupus nephritis, etc.), metabolic disorders (obesity, diabetes, etc.), cardiovascular diseases, gestational complications (preeclampsia, gestational diabetes mellitus, etc.), and cancer (Rourke et al., 2013; Goralski et al., 2019; Gutaj et al., 2020). The gene discussed is RARRES2; the disease is cancer.