It is worth noting that several studies found that long-term exposure with rh-chemerin increases the PTEN expression in hepatocellular carcinoma, prostatic carcinoma, and sarcoma cell lines, thus suppressing the PI3K/Akt signaling pathway (Li et al., 2018; Rennier et al., 2020). The gene discussed is RARRES2; the disease is hepatocellular carcinoma.