Abnormal P38MAPK function is associated with cancer development and patient survival time, it mediates the Fas/Fas L apoptosis pathway by promoting p53 and c-jun phosphorylation, which induces Bax translocation, thereby activating the mitochondrial apoptosis pathway and ultimately promoting apoptosis (Feng et al., 2018; Fei et al., 2020). Here, TP53 is linked to cancer.