Excessive production of NO in NOS may lead to neuronal excitability toxicity and energy consumption, and is accompanied by the generation of ROS include nitrite peroxide and superoxide, these substances can cause oxidative stress injury of brain tissue, leading to a series of nerve pathological process, such as neurodegenerative diseases, inflammation, and cause cerebral ischemia reperfusion injury [30, 31]. This evidence concerns the gene NOS2 and neurodegenerative disease.