Our experimental results showed that GABA decreased in α-Syn transgenic mice, but the content of succinate increased, it is speculated that GABA deficiency, resulting in increased cholinesterase activity, accelerated hydrolysis of acetylcholine, decreased ALDH2 content, mitochondrial dysfunction, resulting in nerve impulse conduction disorders, affecting the normal function of the nerve. Here, BCHE is linked to conduction system disorder.