AFP and hepatocellular carcinoma: According to TCGA, we found that the AUC of TUBG1 was >0.9, with the value being superior to that of AFP (sensitivity of 41%–65% and specificity of 80%–94% for elevated serum AFP levels of >20 ng/mL in diagnosing HCC (Wong, Ahmed & Gish, 2015), which is one of the most common biomarkers for HCC diagnosis.