ACE2 and COVID-19: In addition to the ACE2-mediated direct infection of neuronal cells described above, the nasal cavity, consisting of the sieve plate and olfactory epithelium, establishes a contact with the nerve center, and the severe acute respiratory syndrome virus infection of the nervous system via this pathway also provides new inspiration, that is, whether COVID-19 can also invade the nervous system along this pathway (Baig et al., 2020)?