ESR1 and chronic obstructive pulmonary disease: The active components in BHC may play pivotal roles in anti-COPD through the core targets such as JUN, AKT1, HSP90AA1, SRC, TP53, TNF, IL6, RELA, ESR1, EGFR, MAPK1, GRB2, MAPK14, MYC, and FOS.