The active components in BHC may play pivotal roles in anti-COPD through the core targets such as JUN, AKT1, HSP90AA1, SRC, TP53, TNF, IL6, RELA, ESR1, EGFR, MAPK1, GRB2, MAPK14, MYC, and FOS. Here, TNF is linked to chronic obstructive pulmonary disease.