The active components in BHC may play pivotal roles in anti-COPD through the core targets such as JUN, AKT1, HSP90AA1, SRC, TP53, TNF, IL6, RELA, ESR1, EGFR, MAPK1, GRB2, MAPK14, MYC, and FOS. This evidence concerns the gene GRB2 and chronic obstructive pulmonary disease.