WNK2 and non-small cell lung carcinoma: The results of KEGG enrichment analysis indicated that multiple signaling pathways were involved in the ADI treatment of NSCLC, which included the MAPK signaling pathway, the IL-17 signaling pathway, and PI3K/AKT signaling pathway, etc. Mitogen-activated protein kinase (MAPK) is an important transmitter of signals from the cell surface to the nucleus, which is a group that can be activated by different extracellular stimuli, such as cytokines, neurotransmitters, hormones, cell stress, and cell adhesion.