IAPP and amyloidosis: Both natively folded proteins, such as insulin, transthyretin, β2-microglobulin, and lysozyme, and intrinsically disordered proteins, such as amyloid-β peptide (Aβ), α-synuclein (α-Syn), prion protein, microtubule-associated protein (tau), islet amyloid polypeptide (IAPP), and Huntingtin exon 1, are the best-known proteins that cause amyloidosis (Dobson, 2003).